TLR4 counteracts BVRA signaling in human leukocytes via differential regulation of AMPK, mTORC1 and mTORC2

TLR4 is implicated in diseases associated with chronic low-grade inflammation, yet homeostatic signaling mechanisms that prevent and/or are affected by chronic TLR4 activation are largely uncharacterized. We recently reported that LPS/TLR4 activates in human leukocytes signaling intermediates (SI),...

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Foilsithe in:Sci Rep
Main Authors: Zhang, Zhiyong, Amorosa, Louis F., Petrova, Anna, Coyle, Susette, Macor, Marie, Nair, Mohan, Lee, Leonard Y., Haimovich, Beatrice
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2019
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504875/
https://ncbi.nlm.nih.gov/pubmed/31065010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43347-8
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