Proteolytic cleavage of AMPKα and intracellular MMP9 expression are both required for TLR4-mediated mTORC1 activation and HIF-1α expression in leukocytes

LPS-induced TLR4 activation alters cellular bioenergetics and triggers proteolytic cleavage of AMPKα and HIF-1α expression in leukocytes. In human leukocytes, and more specifically neutrophils, AMPKα cleavage yields 55- and 35-kD protein fragments. Here we address the mechanism by which AMPKα is cle...

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Publicado no:J Immunol
Main Authors: Zhang, Zhiyong, Amorosa, Louis F., Coyle, Susette M., Macor, Marie A., Lubitz, Sara E., Carson, Jeffrey L., Birnbaum, Morris J., Lee, Leonard Y., Haimovich, Beatrice
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546925/
https://ncbi.nlm.nih.gov/pubmed/26232429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500944
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