Proteolytic cleavage of AMPKα and intracellular MMP9 expression are both required for TLR4-mediated mTORC1 activation and HIF-1α expression in leukocytes

LPS-induced TLR4 activation alters cellular bioenergetics and triggers proteolytic cleavage of AMPKα and HIF-1α expression in leukocytes. In human leukocytes, and more specifically neutrophils, AMPKα cleavage yields 55- and 35-kD protein fragments. Here we address the mechanism by which AMPKα is cle...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Zhang, Zhiyong, Amorosa, Louis F., Coyle, Susette M., Macor, Marie A., Lubitz, Sara E., Carson, Jeffrey L., Birnbaum, Morris J., Lee, Leonard Y., Haimovich, Beatrice
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546925/
https://ncbi.nlm.nih.gov/pubmed/26232429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500944
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker