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Activation of AMPK/TSC2/PLD by Alcohol Regulates mTORC1 and mTORC2 Assembly in C2C12 Myocytes
BACKGROUND: Ethanol (EtOH) decreases muscle protein synthesis, and this is associated with reduced mTORC1 and increased mTORC2 activities. In contrast, phospholipase D (PLD) and its metabolite phosphatidic acid (PA) positively regulate mTORC1 signaling, whereas their role in mTORC2 function is less...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3812405/ https://ncbi.nlm.nih.gov/pubmed/23895284 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.12174 |
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