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Activation of AMPK/TSC2/PLD by Alcohol Regulates mTORC1 and mTORC2 Assembly in C2C12 Myocytes

BACKGROUND: Ethanol (EtOH) decreases muscle protein synthesis, and this is associated with reduced mTORC1 and increased mTORC2 activities. In contrast, phospholipase D (PLD) and its metabolite phosphatidic acid (PA) positively regulate mTORC1 signaling, whereas their role in mTORC2 function is less...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Hong-Brown, Ly Q., Brown, C. Randell, Navaratnarajah, Maithili, Lang, Charles H.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3812405/
https://ncbi.nlm.nih.gov/pubmed/23895284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acer.12174
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