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Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity

Various mutations in the structural proteins nebulin and titin that are present in human disease are known to affect the contractility of striated muscle. Loss of nebulin is associated with reduced actin filament length and impairment of myosin binding to actin, whereas titin is thought to regulate...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Gen Physiol
Main Authors: Mijailovich, Srboljub M., Stojanovic, Boban, Nedic, Djordje, Svicevic, Marina, Geeves, Michael A., Irving, Thomas C., Granzier, Henk L.
Format: Artigo
Jezik:Inglês
Izdano: Rockefeller University Press 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504291/
https://ncbi.nlm.nih.gov/pubmed/30948421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812165
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