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Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity

Various mutations in the structural proteins nebulin and titin that are present in human disease are known to affect the contractility of striated muscle. Loss of nebulin is associated with reduced actin filament length and impairment of myosin binding to actin, whereas titin is thought to regulate...

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Pubblicato in:J Gen Physiol
Autori principali: Mijailovich, Srboljub M., Stojanovic, Boban, Nedic, Djordje, Svicevic, Marina, Geeves, Michael A., Irving, Thomas C., Granzier, Henk L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Rockefeller University Press 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6504291/
https://ncbi.nlm.nih.gov/pubmed/30948421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201812165
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