Wordt geladen...
Mapping functional substrate-enzyme interactions in the pol β active site through chemical biology: Structural responses to acidity modification of incoming dNTPs
We report high-resolution crystal structures of DNA polymerase (pol) β in ternary complex with a panel of incoming dNTPs carrying acidity-modified 5′-triphosphate groups. These novel dNTP analogues have a variety of halomethylene substitutions replacing the bridging oxygen between Pβ and Pγ of the i...
Bewaard in:
| Gepubliceerd in: | Biochemistry |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
2018
|
| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6503961/ https://ncbi.nlm.nih.gov/pubmed/29874056 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00418 |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|