Equatorial Active Site Compaction and Electrostatic Reorganization in Catechol-O-methyltransferase

[Image: see text] Catechol-O-methyltransferase (COMT) is a model S-adenosyl-l-methionine (SAM) dependent methyl transferase, which catalyzes the methylation of catecholamine neurotransmitters such as dopamine in the primary pathway of neurotransmitter deactivation in animals. Despite extensive study...

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Опубликовано в: :ACS Catal
Главные авторы: Czarnota, Sylwia, Johannissen, Linus O., Baxter, Nicola J., Rummel, Felix, Wilson, Alex L., Cliff, Matthew J., Levy, Colin W., Scrutton, Nigel S., Waltho, Jonathan P., Hay, Sam
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2019
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503465/
https://ncbi.nlm.nih.gov/pubmed/31080692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.9b00174
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