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Role of the C-terminal domain in inactivation of brain and cardiac sodium channels

Inactivation is a fundamental characteristic of Na(+) channels, and small changes cause skeletal muscle paralysis and myotonia, epilepsy, and cardiac arrhythmia. Brain Na(v)1.2a channels have faster inactivation than cardiac Na(v)1.5 channels, but minor differences in inactivation gate structure are...

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Bibliografiske detaljer
Main Authors: Mantegazza, Massimo, Yu, Frank H., Catterall, William A., Scheuer, Todd
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC65032/
https://ncbi.nlm.nih.gov/pubmed/11742069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.211563298
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