Molecular determinants of drug access to the receptor site for antiarrhythmic drugs in the cardiac Na+ channel.
The clinical efficacy of local anesthetic and antiarrhythmic drugs is due to their voltage- and frequency-dependent block of Na+ channels. Quaternary local anesthetic analogs such as QX-314, which are permanently charged and membrane-impermeant, effectively block cardiac Na+ channels when applied fr...
Na minha lista:
| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1995
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC40498/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8524860/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.25.11839 |
| Tags: |
Sem tags, seja o primeiro a adicionar uma tag!
|