A mutation in segment IVS6 disrupts fast inactivation of sodium channels.
Na(+)-channel inactivation is proposed to occur by binding of an intracellular inactivation gate to a hydrophobic inactivation gate receptor in the intracellular mouth of the pore. Amino acid residues in transmembrane segment S6 of domain IV (IVS6) that are critical for fast inactivation were identi...
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| Udgivet i: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1994
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45434/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991630/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.12346 |
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