USP7: Novel Drug Target in Cancer Therapy

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation. Full activity of USP7 requires the C-terminal Ub-like domains fold back onto the catalytic domain, allowing the remodeling of the active site to a...

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Publicat a:Front Pharmacol
Autors principals: Wang, Zhiru, Kang, Wenting, You, Yinghua, Pang, Jingru, Ren, Hongmei, Suo, Zhenhe, Liu, Hongmin, Zheng, Yichao
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6502913/
https://ncbi.nlm.nih.gov/pubmed/31114498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00427
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