Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing

Targeting immune checkpoints such as programmed cell death protein 1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved for treating melanoma, gastric cancer (GC) and bladder cancer with clinical benefit. Nevertheless, many patients failed to respond to anti-PD-1/PD-L1 treatment, so it...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Wang, Zhiru, Kang, Wenting, Li, Ouwen, Qi, Fengyu, Wang, Junwei, You, Yinghua, He, Pengxing, Suo, Zhenhe, Zheng, Yichao, Liu, Hong-Min
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982505/
https://ncbi.nlm.nih.gov/pubmed/33777676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.11.005
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