Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing

The ataxia telangiectasia and Rad3-related (ATR) kinase plays a crucial role in maintaining genome stability in response to DNA damage. Once activated, ATR acts via its downstream target to arrest the cell cycle, promote DNA repair, and enhance cell survival. Therefore, ATR has become an attractive...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Am J Cancer Res
Auteurs principaux: Sun, Lin-Lin, Yang, Ri-Yao, Li, Chia-Wei, Chen, Mei-Kuang, Shao, Bin, Hsu, Jung-Mao, Chan, Li-Chuan, Yang, Yi, Hsu, Jennifer L, Lai, Yun-Ju, Hung, Mien-Chie
Format: Artigo
Langue:Inglês
Publié: e-Century Publishing Corporation 2018
Sujets:
Original Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079156/
https://ncbi.nlm.nih.gov/pubmed/30094103
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires