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Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing
The ataxia telangiectasia and Rad3-related (ATR) kinase plays a crucial role in maintaining genome stability in response to DNA damage. Once activated, ATR acts via its downstream target to arrest the cell cycle, promote DNA repair, and enhance cell survival. Therefore, ATR has become an attractive...
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| Опубликовано в: : | Am J Cancer Res |
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| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
e-Century Publishing Corporation
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6079156/ https://ncbi.nlm.nih.gov/pubmed/30094103 |
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