Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing

The ataxia telangiectasia and Rad3-related (ATR) kinase plays a crucial role in maintaining genome stability in response to DNA damage. Once activated, ATR acts via its downstream target to arrest the cell cycle, promote DNA repair, and enhance cell survival. Therefore, ATR has become an attractive...

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Detalles Bibliográficos
Publicado en:Am J Cancer Res
Main Authors: Sun, Lin-Lin, Yang, Ri-Yao, Li, Chia-Wei, Chen, Mei-Kuang, Shao, Bin, Hsu, Jung-Mao, Chan, Li-Chuan, Yang, Yi, Hsu, Jennifer L, Lai, Yun-Ju, Hung, Mien-Chie
Formato: Artigo
Idioma:Inglês
Publicado: e-Century Publishing Corporation 2018
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6079156/
https://ncbi.nlm.nih.gov/pubmed/30094103
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