An Expandable Mechanopharmaceutical Device (1): Measuring the Cargo Capacity of Macrophages in a Living Organism

PURPOSE: Clofazimine (CFZ) is an FDA-approved, poorly soluble small molecule drug that precipitates as crystal-like drug inclusions (CLDIs) which accumulate in acidic cytoplasmic organelles of macrophages. In this study, we considered CLDIs as an expandable mechanopharmaceutical device, to study how...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Rzeczycki, Phillip, Woldemichael, Tehetina, Willmer, Andrew, Murashov, Mikhail D., Baik, Jason, Keswani, Rahul, Yoon, Gi Sang, Stringer, Kathleen A., Rodriguez-Hornedo, Nair, Rosania, Gus R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501569/
https://ncbi.nlm.nih.gov/pubmed/30421091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-018-2539-6
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