Cinobufagin suppresses colorectal cancer angiogenesis by disrupting the endothelial mammalian target of rapamycin/hypoxia‐inducible factor 1α axis

Inducing angiogenesis is a hallmark of cancers that sustains tumor growth and metastasis. Neovascularization is a surprisingly early event during the multistage progression of cancer. Cinobufagin, an important bufadienolide originating from Chan Su, has been clinically used to treat cancer in China...

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Bibliografische gegevens
Gepubliceerd in:Cancer Sci
Hoofdauteurs: Li, Xiaowu, Chen, Chunhui, Dai, Yu, Huang, Chengzhi, Han, Qinrui, Jing, Linlin, Ma, Ye, Xu, Yihua, Liu, Yawei, Zhao, Liang, Wang, Junjiang, Sun, Xuegang, Yao, Xueqing
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley and Sons Inc. 2019
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Original Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501006/
https://ncbi.nlm.nih.gov/pubmed/30839155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13988
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