Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK

BACKGROUND: Previous studies showed sanguinarine induced apoptosis in CRC cells but did not define the underlying mechanisms. The purpose of this work was to determine the in vivo and in vitro effects of sanguinarine on CRC tumors and to elucidate the mechanism in regulating the intrinsic apoptosis....

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Détails bibliographiques
Publié dans:BMC Cancer
Auteurs principaux: Gong, Xianling, Chen, Zhihong, Han, Qinrui, Chen, Chunhui, Jing, Linlin, Liu, Yawei, Zhao, Liang, Yao, Xueqing, Sun, Xuegang
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5963096/
https://ncbi.nlm.nih.gov/pubmed/29783958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4463-x
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