Cinobufagin suppresses colorectal cancer angiogenesis by disrupting the endothelial mammalian target of rapamycin/hypoxia‐inducible factor 1α axis

Inducing angiogenesis is a hallmark of cancers that sustains tumor growth and metastasis. Neovascularization is a surprisingly early event during the multistage progression of cancer. Cinobufagin, an important bufadienolide originating from Chan Su, has been clinically used to treat cancer in China...

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Detalhes bibliográficos
Publicado no:Cancer Sci
Main Authors: Li, Xiaowu, Chen, Chunhui, Dai, Yu, Huang, Chengzhi, Han, Qinrui, Jing, Linlin, Ma, Ye, Xu, Yihua, Liu, Yawei, Zhao, Liang, Wang, Junjiang, Sun, Xuegang, Yao, Xueqing
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6501006/
https://ncbi.nlm.nih.gov/pubmed/30839155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cas.13988
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