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Unified energetics analysis unravels SpCas9 cleavage activity for optimal gRNA design
While CRISPR/Cas9 is a powerful tool in genome engineering, the on-target activity and off-target effects of the system widely vary because of the differences in guide RNA (gRNA) sequences and genomic environments. Traditional approaches rely on separate models and parameters to treat on- and off-ta...
Gorde:
| Argitaratua izan da: | Proc Natl Acad Sci U S A |
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| Egile Nagusiak: | , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
National Academy of Sciences
2019
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6500161/ https://ncbi.nlm.nih.gov/pubmed/30988204 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1820523116 |
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