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Structural insights into a high fidelity variant of SpCas9
The RNA-guided endonucleases of the CRISPR-Cas9 system, including the most widely used Cas9 from Streptococcus pyogenes (SpCas9), are becoming a robust genome editing tool in model organisms and hold immense promise for therapeutic applications. Many strategies have been employed to overcome the lim...
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| Publicado no: | Cell Res |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6460432/ https://ncbi.nlm.nih.gov/pubmed/30664728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41422-018-0131-6 |
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