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Blackjack mutations improve the on-target activities of increased fidelity variants of SpCas9 with 5′G-extended sgRNAs

Increased fidelity mutants of the SpCas9 nuclease constitute the most promising approach to mitigating its off-target effects. However, these variants are effective only in a restricted target space, and many of them are reported to work less efficiently when applied in clinically relevant, pre-asse...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kulcsár, Péter István, Tálas, András, Tóth, Eszter, Nyeste, Antal, Ligeti, Zoltán, Welker, Zsombor, Welker, Ervin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7060260/
https://ncbi.nlm.nih.gov/pubmed/32144253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-15021-5
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