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Select sequencing of clonally expanded CD8(+) T cells reveals limits to clonal expansion
To permit the recognition of antigens, T cells generate a vast diversity of T cell receptor (TCR) sequences. Upon binding of the TCR to an antigen–MHC complex, T cells clonally expand to establish an immune response. To study antigen-specific T cell clonality, we have developed a method that allows...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6500157/ https://ncbi.nlm.nih.gov/pubmed/30992377 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902649116 |
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