Select sequencing of clonally expanded CD8(+) T cells reveals limits to clonal expansion

To permit the recognition of antigens, T cells generate a vast diversity of T cell receptor (TCR) sequences. Upon binding of the TCR to an antigen–MHC complex, T cells clonally expand to establish an immune response. To study antigen-specific T cell clonality, we have developed a method that allows...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Huang, Huang, Sikora, Michael J., Islam, Saiful, Chowdhury, Roshni Roy, Chien, Yueh-hsiu, Scriba, Thomas J., Davis, Mark M., Steinmetz, Lars M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2019
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PNAS Plus
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500157/
https://ncbi.nlm.nih.gov/pubmed/30992377
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1902649116
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