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Detection, phenotyping, and quantification of antigen-specific T cells using a peptide-MHC dodecamer

Here we report a peptide-MHC (pMHC) dodecamer as a “next generation” technology that is a significantly more sensitive and versatile alternative to pMHC tetramers for the detection, isolation, and phenotypic analysis of antigen-specific T cells. In particular, dodecamers are able to detect two- to f...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Huang, Jun, Zeng, Xun, Sigal, Natalia, Lund, Peder J., Su, Laura F., Huang, Huang, Chien, Yueh-hsiu, Davis, Mark M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4822615/
https://ncbi.nlm.nih.gov/pubmed/26979955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1602488113
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