Peptide-MHC-I from Endogenous Antigen Outnumber Those from Exogenous Antigen, Irrespective of APC Phenotype or Activation

Naïve anti-viral CD8(+) T cells (T(CD8+)) are activated by the presence of peptide-MHC Class I complexes (pMHC-I) on the surface of professional antigen presenting cells (pAPC). Increasing the number of pMHC-I in vivo can increase the number of responding T(CD8+). Antigen can be presented directly o...

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Publicado en:PLoS Pathog
Autores principales: Sei, Janet J., Haskett, Scott, Kaminsky, Lauren W., Lin, Eugene, Truckenmiller, Mary E., Bellone, Clifford J., Buller, R. Mark, Norbury, Christopher C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4479883/
https://ncbi.nlm.nih.gov/pubmed/26107264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004941
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