Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution

The genetic and morphological development of colorectal cancer is a paradigm for tumorigenesis. However, the dynamics of clonal evolution underpinning carcinogenesis remain poorly understood. Here we identify multipotential stem cells within human colorectal adenomas and use methylation patterns of...

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Bibliographic Details
Main Authors: Humphries, Adam, Cereser, Biancastella, Gay, Laura J., Miller, Daniel S. J., Das, Bibek, Gutteridge, Alice, Elia, George, Nye, Emma, Jeffery, Rosemary, Poulsom, Richard, Novelli, Marco R., Rodriguez-Justo, Manuel, McDonald, Stuart A. C., Wright, Nicholas A., Graham, Trevor A.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2013
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3704042/
https://ncbi.nlm.nih.gov/pubmed/23766371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220353110
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