Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion

T-cell immunity requires extremely rapid clonal proliferation of rare, antigen-specific T lymphocytes to form effector cells. Here we identify a critical role for ETAA1 in this process by surveying random germ line mutations in mice using exome sequencing and bioinformatic annotation to prioritize m...

Cur síos iomlán

Na minha lista:
Sonraí Bibleagrafaíochta
Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Miosge, Lisa A., Sontani, Yovina, Chuah, Aaron, Horikawa, Keisuke, Russell, Tiffany A., Mei, Yan, Wagle, Mayura V., Howard, Debbie R., Enders, Anselm, Tscharke, David C., Goodnow, Christopher C., Parish, Ian A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2017
Ábhair:
PNAS Plus
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495275/
https://ncbi.nlm.nih.gov/pubmed/28607084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705795114
Clibeanna: Cuir Clib Leis
Gan Chlibeanna, Bí ar an gcéad duine leis an taifead seo a chlibeáil!

Míreanna Comhchosúla