Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion

T-cell immunity requires extremely rapid clonal proliferation of rare, antigen-specific T lymphocytes to form effector cells. Here we identify a critical role for ETAA1 in this process by surveying random germ line mutations in mice using exome sequencing and bioinformatic annotation to prioritize m...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Miosge, Lisa A., Sontani, Yovina, Chuah, Aaron, Horikawa, Keisuke, Russell, Tiffany A., Mei, Yan, Wagle, Mayura V., Howard, Debbie R., Enders, Anselm, Tscharke, David C., Goodnow, Christopher C., Parish, Ian A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2017
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495275/
https://ncbi.nlm.nih.gov/pubmed/28607084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705795114
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