Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion

T-cell immunity requires extremely rapid clonal proliferation of rare, antigen-specific T lymphocytes to form effector cells. Here we identify a critical role for ETAA1 in this process by surveying random germ line mutations in mice using exome sequencing and bioinformatic annotation to prioritize m...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Miosge, Lisa A., Sontani, Yovina, Chuah, Aaron, Horikawa, Keisuke, Russell, Tiffany A., Mei, Yan, Wagle, Mayura V., Howard, Debbie R., Enders, Anselm, Tscharke, David C., Goodnow, Christopher C., Parish, Ian A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495275/
https://ncbi.nlm.nih.gov/pubmed/28607084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705795114
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