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Ubiquitylation of CD98 limits cell proliferation and clonal expansion

CD98 heavy chain (SLC3A2) facilitates lymphocyte clonal expansion that enables adaptive immunity; however, increased expression of CD98 is also a feature of both lymphomas and leukemias and represents a potential therapeutic target in these diseases. CD98 is transcriptionally regulated and ectopic e...

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Bibliografiske detaljer
Udgivet i:J Cell Sci
Main Authors: Ablack, Jailal N. G., Metz, Patrick J., Chang, John T., Cantor, Joseph M., Ginsberg, Mark H.
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4712820/
https://ncbi.nlm.nih.gov/pubmed/26493331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.178129
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