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Ubiquitylation of CD98 limits cell proliferation and clonal expansion
CD98 heavy chain (SLC3A2) facilitates lymphocyte clonal expansion that enables adaptive immunity; however, increased expression of CD98 is also a feature of both lymphomas and leukemias and represents a potential therapeutic target in these diseases. CD98 is transcriptionally regulated and ectopic e...
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| Veröffentlicht in: | J Cell Sci |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Company of Biologists
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4712820/ https://ncbi.nlm.nih.gov/pubmed/26493331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.178129 |
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