Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity

Nephrotoxicity is a critical adverse event that leads to discontinuation of kinase inhibitor (KI) treatment. Here we show, through meta-analyses of FDA Adverse Event Reporting System, that dasatinib is associated with high risk for glomerular toxicity that is uncoupled from hypertension, suggesting...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Calizo, Rhodora C., Bhattacharya, Smiti, van Hasselt, J. G. Coen, Wei, Chengguo, Wong, Jenny S., Wiener, Robert J., Ge, Xuhua, Wong, Nicholas J., Lee, Jia-Jye, Cuttitta, Christina M., Jayaraman, Gomathi, Au, Vivienne H., Janssen, William, Liu, Tong, Li, Hong, Salem, Fadi, Jaimes, Edgar A., Murphy, Barbara, Campbell, Kirk N., Azeloglu, Evren U.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499885/
https://ncbi.nlm.nih.gov/pubmed/31053734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09936-x
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires