The Hippo pathway regulator KIBRA promotes podocyte injury by inhibiting YAP signaling and disrupting actin cytoskeletal dynamics

Kidney podocytes represent a key constituent of the glomerular filtration barrier. Identifying the molecular mechanisms of podocyte injury and survival is important for better understanding and management of kidney diseases. KIBRA (kidney brain protein), an upstream regulator of the Hippo signaling...

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Vydáno v:J Biol Chem
Hlavní autoři: Meliambro, Kristin, Wong, Jenny S., Ray, Justina, Calizo, Rhodora C., Towne, Sara, Cole, Beatriz, El Salem, Fadi, Gordon, Ronald E., Kaufman, Lewis, He, John C., Azeloglu, Evren U., Campbell, Kirk N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
Molecular Bases of Disease
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743086/
https://ncbi.nlm.nih.gov/pubmed/28982981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.819029
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