A biomimetic gelatin-based platform elicits a pro-differentiation effect on podocytes through mechanotransduction

Using a gelatin microbial transglutaminase (gelatin-mTG) cell culture platform tuned to exhibit stiffness spanning that of healthy and diseased glomeruli, we demonstrate that kidney podocytes show marked stiffness sensitivity. Podocyte-specific markers that are critical in the formation of the renal...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Hu, Mufeng, Azeloglu, Evren U., Ron, Amit, Tran-Ba, Khanh-Hoa, Calizo, Rhodora C., Tavassoly, Iman, Bhattacharya, Smiti, Jayaraman, Gomathi, Chen, Yibang, Rabinovich, Vera, Iyengar, Ravi, Hone, James C., He, John C., Kaufman, Laura J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5338254/
https://ncbi.nlm.nih.gov/pubmed/28262745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43934
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