Disruption of podocyte cytoskeletal biomechanics by dasatinib leads to nephrotoxicity

Nephrotoxicity is a critical adverse event that leads to discontinuation of kinase inhibitor (KI) treatment. Here we show, through meta-analyses of FDA Adverse Event Reporting System, that dasatinib is associated with high risk for glomerular toxicity that is uncoupled from hypertension, suggesting...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Calizo, Rhodora C., Bhattacharya, Smiti, van Hasselt, J. G. Coen, Wei, Chengguo, Wong, Jenny S., Wiener, Robert J., Ge, Xuhua, Wong, Nicholas J., Lee, Jia-Jye, Cuttitta, Christina M., Jayaraman, Gomathi, Au, Vivienne H., Janssen, William, Liu, Tong, Li, Hong, Salem, Fadi, Jaimes, Edgar A., Murphy, Barbara, Campbell, Kirk N., Azeloglu, Evren U.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499885/
https://ncbi.nlm.nih.gov/pubmed/31053734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09936-x
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