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Total Synthesis of (–)-Xylogranatopyridine B via a Palladium-Catalyzed Oxidative Stannylation of Enones

We report a total synthesis of the pyridine-containing limonoid alkaloid (–)-xylogranatopyridine B in 11 steps from commercially available dihydrocarvone. The central pyridine ring was assembled by a late-stage fragment coupling approach employing a modified Liebeskind pyridine synthesis. One fragme...

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Détails bibliographiques
Publié dans:J Am Chem Soc
Auteurs principaux: Schuppe, Alexander W., Huang, David, Chen, Yifeng, Newhouse, Timothy R.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499388/
https://ncbi.nlm.nih.gov/pubmed/29338207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b13189
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