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An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis.

Herein we describe the direct enantioselective Lewis base/Pd catalysed α-allylation of pyrrole acetic acid esters. This provides high isolated yields of highly enantioenriched products and exhibits broad reaction scope with respect to both reaction partners. The products can be readily elaborated in...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Org Biomol Chem
Prif Awduron: Scaggs, W. Rush, Scaggs, Toya D., Snaddon, Thomas N.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499370/
https://ncbi.nlm.nih.gov/pubmed/30483696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c8ob02600a
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