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Enantioselective Synthesis of α‐Aryl‐β(2)‐Amino‐Esters by Cooperative Isothiourea and Brønsted Acid Catalysis

The synthesis of α‐aryl‐β(2)‐amino esters through enantioselective aminomethylation of an arylacetic acid ester in high yields and enantioselectivity via cooperative isothiourea and Brønsted acid catalysis is demonstrated. The scope and limitations of this process are explored (25 examples, up to 94...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Zhao, Feng, Shu, Chang, Young, Claire M., Carpenter‐Warren, Cameron, Slawin, Alexandra M. Z., Smith, Andrew D.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252622/
https://ncbi.nlm.nih.gov/pubmed/33646631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202016220
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