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Enantioselective Synthesis of α‐Aryl‐β(2)‐Amino‐Esters by Cooperative Isothiourea and Brønsted Acid Catalysis

The synthesis of α‐aryl‐β(2)‐amino esters through enantioselective aminomethylation of an arylacetic acid ester in high yields and enantioselectivity via cooperative isothiourea and Brønsted acid catalysis is demonstrated. The scope and limitations of this process are explored (25 examples, up to 94...

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Detalles Bibliográficos
Publicado en:Angew Chem Int Ed Engl
Main Authors: Zhao, Feng, Shu, Chang, Young, Claire M., Carpenter‐Warren, Cameron, Slawin, Alexandra M. Z., Smith, Andrew D.
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2021
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252622/
https://ncbi.nlm.nih.gov/pubmed/33646631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202016220
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