Enantioselective Synthesis of α‐Aryl‐β(2)‐Amino‐Esters by Cooperative Isothiourea and Brønsted Acid Catalysis

The synthesis of α‐aryl‐β(2)‐amino esters through enantioselective aminomethylation of an arylacetic acid ester in high yields and enantioselectivity via cooperative isothiourea and Brønsted acid catalysis is demonstrated. The scope and limitations of this process are explored (25 examples, up to 94...

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Bibliographic Details
Published in:Angew Chem Int Ed Engl
Main Authors: Zhao, Feng, Shu, Chang, Young, Claire M., Carpenter‐Warren, Cameron, Slawin, Alexandra M. Z., Smith, Andrew D.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2021
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8252622/
https://ncbi.nlm.nih.gov/pubmed/33646631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202016220
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