Загрузка...
Identification of a small molecule inhibitor of Sir2p
Sir2p is an NAD(+)-dependent histone deacetylase required for chromatin-dependent silencing in yeast. In a cell-based screen for inhibitors of Sir2p, we identified a compound, splitomicin, that creates a conditional phenocopy of a sir2 deletion mutant in Saccharomyces cerevisiae. Cells grown in the...
Сохранить в:
| Главные авторы: | , , , , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The National Academy of Sciences
2001
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC64992/ https://ncbi.nlm.nih.gov/pubmed/11752457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.261574398 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|