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Identification of small molecule inhibitors of the Chikungunya virus nsP1 RNA capping enzyme

Chikungunya virus (CHIKV) is an arthropod-borne alphavirus. Alphaviruses are positive strand RNA viruses that require a 5´ cap structure to direct translation of the viral polyprotein and prevent degradation of the viral RNA genome by host cell nucleases. Formation of the 5´ RNA cap is orchestrated...

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Bibliografische gegevens
Gepubliceerd in:Antiviral Res
Hoofdauteurs: Feibelman, Kristen M., Fuller, Benjamin P., Li, Linfeng, LaBarbera, Daniel V., Geiss, Brian J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5966835/
https://ncbi.nlm.nih.gov/pubmed/29680670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2018.03.013
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