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The TwistDock workflow for evaluation of bivalent Smac mimetics targeting XIAP
Purpose: Mimetics based on Smac, the native inhibitor of XIAP, are promising drug-candidates for the treatment of cancer. Bivalent Smac mimetics inhibit XIAP with even higher potency than monovalent mimetics, but how to optimize the linker that tethers the two monovalent binding motifs remains contr...
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| Publicado no: | Drug Des Devel Ther |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Dove
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6499140/ https://ncbi.nlm.nih.gov/pubmed/31118573 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S194276 |
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