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A Dimeric Smac/Diablo Peptide Directly Relieves Caspase-3 Inhibition by XIAP: Dynamic and Cooperative Regulation of XIAP by Smac/Diablo

Caspase activation, the executing event of apoptosis, is under deliberate regulation. IAP proteins inhibit caspase activity whereas Smac/Diablo antagonizes IAP. XIAP, a ubiquitous IAP, can inhibit both caspase-9, the initiator caspase of the mitochondrial apoptotic pathway, and the downstream effect...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Gao, Zhonghua, Tian, Yuan, Wang, Junru, Yin, Qian, Wu, Hao, Li, Yue-Ming, Jiang, Xuejun
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2007
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3202417/
https://ncbi.nlm.nih.gov/pubmed/17724022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M705258200
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