The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo

ARTS (Sept4_i2) is a pro-apoptotic tumor suppressor protein that functions as an antagonist of X-linked IAP (XIAP) to promote apoptosis. It is generally thought that mitochondrial outer membrane permeabilization (MOMP) occurs before activation of caspases and is required for it. Here, we show that A...

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Autori principali: Edison, N, Zuri, D, Maniv, I, Bornstein, B, Lev, T, Gottfried, Y, Kemeny, S, Garcia-Fernandez, M, Kagan, J, Larisch, S
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Original Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263492/
https://ncbi.nlm.nih.gov/pubmed/21869827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.112
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