The IAP-antagonist ARTS initiates caspase activation upstream of cytochrome C and SMAC/Diablo

ARTS (Sept4_i2) is a pro-apoptotic tumor suppressor protein that functions as an antagonist of X-linked IAP (XIAP) to promote apoptosis. It is generally thought that mitochondrial outer membrane permeabilization (MOMP) occurs before activation of caspases and is required for it. Here, we show that A...

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Hlavní autoři: Edison, N, Zuri, D, Maniv, I, Bornstein, B, Lev, T, Gottfried, Y, Kemeny, S, Garcia-Fernandez, M, Kagan, J, Larisch, S
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3263492/
https://ncbi.nlm.nih.gov/pubmed/21869827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2011.112
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