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The Recognition of Unrelated Ligands by Identical Proteins

Unrelated ligands, often found in drug discovery campaigns, can bind to the same receptor, even with the same protein residues. To investigate how this might occur, and whether it might be typically possible to find unrelated ligands for the same drug target, we sought examples of topologically unre...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:ACS Chem Biol
Päätekijät: Pottel, Joshua, Levit, Anat, Korczynska, Magdalena, Fischer, Marcus, Shoichet, Brian K.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499068/
https://ncbi.nlm.nih.gov/pubmed/30095890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00443
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