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The Recognition of Identical Ligands by Unrelated Proteins

The binding of drugs and reagents to off-targets is well-known. Whereas many off-targets are related to the primary target by sequence and fold, many ligands bind to unrelated pairs of proteins, and these are harder to anticipate. If the binding site in the off-target can be related to that of the p...

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Pubblicato in:ACS Chem Biol
Autori principali: Barelier, Sarah, Sterling, Teague, O'Meara, Matthew J., Shoichet, Brian K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4684825/
https://ncbi.nlm.nih.gov/pubmed/26421501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.5b00683
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