Ipriflavone attenuates the degeneration of cartilage by blocking the Indian hedgehog pathway

BACKGROUND: To determine if ipriflavone, a novel and safe inhibitor of Indian hedgehog (Ihh) signaling, can attenuate cartilage degeneration by blocking the Ihh pathway. METHODS: Human chondrocytes were used to evaluate Ihh signaling, cell proliferation, apoptosis, gene, and protein expression of ch...

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Bibliographic Details
Published in:Arthritis Res Ther
Main Authors: Guo, Li, Wei, Xiaochun, Zhang, Zhiwei, Wang, Xiaojian, Wang, Chunli, Li, Pengcui, Wang, Chunfang, Wei, Lei
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498579/
https://ncbi.nlm.nih.gov/pubmed/31046827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-019-1895-x
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