The Effects of Indian Hedgehog Deletion on Mesenchyme Cells: Inducing Intermediate Cartilage Scaffold Ossification to Cause Growth Plate and Phalange Joint Absence, Short Limb, and Dwarfish Phenotypes

The endochondral ossification plays a critical role in vertebrate limb development and skeletal homeostasis, where limb mesenchyme cells form an intermediate cartilage scaffold that develops into growth plates and then replaced by bone. Although Indian hedgehog (Ihh) is known to control the hypertro...

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Dettagli Bibliografici
Pubblicato in:Stem Cells Dev
Autori principali: Sun, Jian, Wei, Xiaochun, Li, Shengchun, Sun, Changqi, Wang, Chunfang, Li, Pengcui, Wei, Dennis L., Wei, Lei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc., publishers 2018
Soggetti:
Original Research Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205051/
https://ncbi.nlm.nih.gov/pubmed/30032718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2018.0071
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