The Effects of Indian Hedgehog Deletion on Mesenchyme Cells: Inducing Intermediate Cartilage Scaffold Ossification to Cause Growth Plate and Phalange Joint Absence, Short Limb, and Dwarfish Phenotypes

The endochondral ossification plays a critical role in vertebrate limb development and skeletal homeostasis, where limb mesenchyme cells form an intermediate cartilage scaffold that develops into growth plates and then replaced by bone. Although Indian hedgehog (Ihh) is known to control the hypertro...

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Dades bibliogràfiques
Publicat a:Stem Cells Dev
Autors principals: Sun, Jian, Wei, Xiaochun, Li, Shengchun, Sun, Changqi, Wang, Chunfang, Li, Pengcui, Wei, Dennis L., Wei, Lei
Format: Artigo
Idioma:Inglês
Publicat: Mary Ann Liebert, Inc., publishers 2018
Matèries:
Original Research Reports
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205051/
https://ncbi.nlm.nih.gov/pubmed/30032718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2018.0071
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