The Effects of Indian Hedgehog Deletion on Mesenchyme Cells: Inducing Intermediate Cartilage Scaffold Ossification to Cause Growth Plate and Phalange Joint Absence, Short Limb, and Dwarfish Phenotypes

The endochondral ossification plays a critical role in vertebrate limb development and skeletal homeostasis, where limb mesenchyme cells form an intermediate cartilage scaffold that develops into growth plates and then replaced by bone. Although Indian hedgehog (Ihh) is known to control the hypertro...

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Detalhes bibliográficos
Publicado no:Stem Cells Dev
Main Authors: Sun, Jian, Wei, Xiaochun, Li, Shengchun, Sun, Changqi, Wang, Chunfang, Li, Pengcui, Wei, Dennis L., Wei, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2018
Assuntos:
Original Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205051/
https://ncbi.nlm.nih.gov/pubmed/30032718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2018.0071
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