The Effects of Indian Hedgehog Deletion on Mesenchyme Cells: Inducing Intermediate Cartilage Scaffold Ossification to Cause Growth Plate and Phalange Joint Absence, Short Limb, and Dwarfish Phenotypes

The endochondral ossification plays a critical role in vertebrate limb development and skeletal homeostasis, where limb mesenchyme cells form an intermediate cartilage scaffold that develops into growth plates and then replaced by bone. Although Indian hedgehog (Ihh) is known to control the hypertro...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Stem Cells Dev
Hauptverfasser: Sun, Jian, Wei, Xiaochun, Li, Shengchun, Sun, Changqi, Wang, Chunfang, Li, Pengcui, Wei, Dennis L., Wei, Lei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc., publishers 2018
Schlagworte:
Original Research Reports
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205051/
https://ncbi.nlm.nih.gov/pubmed/30032718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/scd.2018.0071
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