Early supplemental α2-macroglobulin attenuates cartilage and bone damage by inhibiting inflammation in collagen II-induced arthritis model

OBJECTIVE: To determine if early supplemental intra-articular A2M has a chondroprotective effect in CIA mice model. METHODS: DBA/1 mice were randomized into 4 groups (n =15/group) ：1) CIA + 1.2μg of A2M; 2) CIA + 0.8μg of A2M; 3) CIA + 0.4μg of A2M; 4) Vehicle + PBS. A2M was injected into right ankl...

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Detalhes bibliográficos
Publicado no:Int J Rheum Dis
Main Authors: Li, Shengchun, Xiang, Chuan, Wei, Xiaochun, Sun, Xiaojuan, Li, Ruifang, Li, Pengcui, Sun, Jian, Wei, Dinglu, Chen, Yong, Zhang, Yanxiang, Wei, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465088/
https://ncbi.nlm.nih.gov/pubmed/30609267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/1756-185X.13457
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