Knockdown Indian Hedgehog (Ihh) does not delay Fibular Fracture Healing in genetic deleted Ihh mice and pharmaceutical inhibited Ihh Mice

The objective of this study was to determine if Ihh is required for fracture healing. Fibular fracture was created in adult Col2a1-CreER(T2); Ihh(fl)(/)(fl) mice. Ihh(fl)(/)(fl) mice received Tamoxifen (TM) to delete Ihh. WT mice received Cyclopamine to inhibit Hh pathway. Callus tissue properties a...

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Vydáno v:Sci Rep
Hlavní autoři: Li, Shengchun, Xiang, Chuan, Wei, Xiaochun, Li, Hongbin, Li, Kai, Sun, Xiaojuan, Wang, Shaowei, Zhang, Min, Deng, Jin, Wang, Xiaodu, Li, Pengcui, Li, Ruifang, Zhang, Yanxiang, Wei, Lei
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037729/
https://ncbi.nlm.nih.gov/pubmed/29985470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-28657-7
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