Disrupting the Indian hedgehog signaling pathway in vivo attenuates surgically induced osteoarthritis progression in Col2a1-CreER(T2); Ihh(fl)/(fl) mice

INTRODUCTION: Previous observations implicate Indian hedgehog (Ihh) signaling in osteoarthritis (OA) development because it regulates chondrocyte hypertrophy and matrix metallopeptidase 13 (MMP-13) expression. However, there is no direct genetic evidence for the role of Ihh in OA, because mice with...

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Detalhes bibliográficos
Main Authors: Zhou, Jingming, Chen, Qian, Lanske, Beate, Fleming, Braden C, Terek, Richard, Wei, Xiaochun, Zhang, Ge, Wang, Shaowei, Li, Kai, Wei, Lei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978435/
https://ncbi.nlm.nih.gov/pubmed/24428864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar4437
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