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Attenuation of Cartilage Pathogenesis in Post-traumatic Osteoarthritis in Mice by blocking the Stromal Derived Factor 1 Receptor (CXCR4) with the specific inhibitor, AMD3100
OBJECTIVE: SDF-1 was found to infiltrate cartilage, decrease proteoglycan content, and increase MMP-13 activity after joint trauma. In this study, we tested the hypothesis that interference of the SDF-1/CXCR4 signaling pathway via AMD3100 can attenuate pathogenesis in a mouse model of PTOA. We also...
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| Publicado no: | J Orthop Res |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4557642/ https://ncbi.nlm.nih.gov/pubmed/25732515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jor.22862 |
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